Avi Biopharm ($AVII), sarò matto…

Scritto il alle 15:54 da cerealkiller

o forse ho capito poco dalla vita, ma io non condivido questo scetticismo nei confronti dei risultati. A mio parere la quotazione ad 1$ pe aprire una posizione d’avanguardia è parecchio interessante, per poi magari rintuzzare dopo una eventuale diluizione. Se vi piace fare i cassettisti, questo è il titolo per voi…

AVI BioPharma, Inc. announced that treatment with eteplirsen met the primary efficacy endpoint in a randomized, double-blind, placebo-controlled Phase IIb study in boys with Duchenne muscular dystrophy (DMD). Eteplirsen administered once weekly at 30mg/kg over 24 weeks resulted in a statistically significant (p ≤ 0.002) increase in novel dystrophin (22.5% dystrophin-positive fibers as a percentage of normal) compared to no increase in the placebo group. In the study, a shorter duration of eteplirsen treatment, 12 weeks, did not show a significant increase in novel dystrophin (0.79% dystrophin-positive fibers as a percentage of normal; p-value NS), despite administration of the drug at a higher dose (50mg/kg once weekly). This finding suggests that a longer duration of dosing is required before meaningful levels of dystrophin are produced. There were no significant improvements in clinical outcomes in the treated groups compared to placebo. Performance on the 6-minute walk test and other outcome measures were generally stable across most of the patients, including the placebo patients, suggesting that a longer period of observation will be required to demonstrate clinical effects of eteplirsen versus a placebo control. Eteplirsen was well tolerated at both dose levels through 24 weeks of treatment. There were no treatment-related adverse events, no serious adverse events, and no treatment discontinuations related to eteplirsen.

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1 commento Commenta
Scritto il 2 aprile 2012 at 16:15

per il momento sto alla finestra……

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